Introducing the 500-MS Ion Trap

• Enhanced Charge Capacity provides the 500-MS LC with the capability to detect trace amounts in a high concentration of coeluting analytes in heavy matrices.
• Temperature programmable SelecTemp™ API interface reduces contamination.
• Unidirectional triple resonance scan method preferentially ejects trapped ions toward the detector.
• TurboDDS™ Data dependent scanning option allows MSⁿ for automated qualitative analysis.
• Varian’s Mass ID™ deconvolution software aids in the molecular weight determination of large molecules that are detected as multiply-charged ions, such as proteins, peptides and oligonucleotides.

The Varian 500-MS LC Ion Trap is the instrument of choice for high-throughput LC/MS analysis where sensitivity, reliability and productivity are essential.

The Varian 500-MS provides a robust platform for demanding LC/MS/MS applications. The system sensitivity, mass resolution, and mass stability reflect the ion trap technology’s inherent advantages, while the new enhanced charge capacity extends the number of ions that can be stored in the ion trap resulting in greater sensitivity and reduced background while delivering reliable qualitative and quantitative results.

By delivering excellent sensitivity over the entire mass range in full scan mode, and exceptional MS/MS and MSⁿ capabilities, theVarian 500-MS quickly provides superior information for even the most complex sample matrices."

Sensitivity enhancements include SelecTemp™, the unique temperature programmable API (Atmospheric Pressure Ionization), enabling optimal analysis of thermally labile compounds. All of these technical capabilities lead to the remarkable performance and productivity delivered by the Varian 500-MS LC ion trap.

Doubly Charged Normal 5,000

Singly Charged Fast 15,000

State-of-the-art API capability

The Varian 500-MS delivers increased sensitivity and selectivity through optimized analysis of all analytes, including highly thermally labile compounds, using Varian, Inc.’s patent pending temperature programmable SelecTemp™ API interface. Maintaining sample integrity is no longer a concern. SelecTemp’s programmable temperature control delivers optimum drying gas temperatures at every time point throughout a complex analysis. Additional SelecTemp API benefits include reduced interface contamination, improved throughput, simplified setup and easily recordable parameters for GLP purposes.

Premium scanning and the power of MSⁿ

Achieve unit mass resolution with uncompromised qualitative and quantitative results for narrow or coeluting chromatographic peaks at scan speeds of up to 15,000 Da/sec with the patented ‘unidirectional triple resonance’ scan method that preferentially ejects all the trapped ions toward the detector. The fast scan speed is complemented by rapid ion polarity switching of 200 milliseconds to accommodate the optimum detection of ion polarity for every analyte in the sample. Enhanced qualitative information is delivered by the 500-MS with MSn operation to n=10, expanding the spectral information content for structure elucidation.